中文名 | Triazavirin |
英文名 | Triazavirin |
别名 | 瑞米拉韦 化合物TRIAZAVIRIN 2-甲硫基-6-硝基-1,2,4-三唑并[5,1c][1,2,3]-三嗪-7-酮钠盐二水合物 7-(甲硫基)-3-硝基-[1,2,4]三唑并[5,1-C][1,2,4]三嗪环-4(6H)-酮钠盐二水化合物 |
英文别名 | Triazavirin Triazavirin (Riamilovir) Triazavirin sodium hydrate (TZV, Riamilovir) Sodium 2-methylthio-6-nitro-1,2,4-triazol [5,1c][1,2,3]-triazin-7-one dihydrate Sodium 7-(methylthio)-3-nitro-4-oxo-4H-[1,2,4]triazolo[5,1-c][1,2,4]triazin-6-ide dihydrate 1,2,4]Triazolo[5,1-c][1,2,4]triazin-4(6H)-one, 7-(methylthio)-3-nitro-, sodium salt, hydrate |
CAS | 928659-17-0 |
EINECS | 690-013-3 |
化学式 | C5H7N6NaO4S |
分子量 | 270.2 |
存储条件 | under inert gas (nitrogen or Argon) at 2-8°C |
体外研究 | The efficacy of Triazavirin against the tick-borne encephalitis virus is estimated in the sensitive cell culture. In a concentration of 128 mcg/mL Triazavirin is shown active in inhibition of the tick-borne encephalitis virus reproduction (strain Sofiin ) by accumulation in the SKEV cell culture. |
体内研究 | The therapeutic efficacy Triazavirin against experimental Forest-Spring encephalitis on albino mice is studied. The results shows that in high doses (200-400 mg/kg) Triazavirin moderately protects the infected animals. A significant increase of the animal lifespan in the test groups (from 4.1 to 4.8 days) and a statistically valid decrease of the virus accumulation in the target organ are observed. |
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